Cancer Prevention: What's on the Horizon?

As early as 2006, we were seeing news articles about the possibility of a vaccine coming to market to fight cervical cancer. At that time, the HPV vaccine was in the final stages of research, and was under review by the FDA. In the summer of that year, the vaccine was approved for girls and young women, and was later approved for males as well. It is now considered a vital tool in the prevention of cervical cancer in men and women, and is as close to being a "cure" as we have seen to date.

Just like those conducted on the HPV vaccine, there are hundreds more clinical research trials being done every day that are investigating the effectiveness of newly developed drugs and procedures. Clinical trials are a vital key to removing the word cancer from "household word" status.

Cancer research trials are conducted for many reasons. Some are simply focused on finding a "cure". Sometimes, these lead to discoveries that were unexpected - such as a medication that was being used to treat one kind of cancer that is then found to be effective on another type, or even another disease altogether. In other studies, researchers may be trying to discover ways to manage symptoms or after-effects of treatment such as "chemo-brain" and post-radiation nerve damage. Trials are also conducted that study the psychological impact of medical treatments and offer new "best practices" for doctors in order to prevent patients from suffering emotional distress during their treatment and recovery.

For a patient, the decision to participating in a clinical trial can be a difficult one to make. Many trials are "double-blind", meaning that the doctor and the patient don't know if the syringe or i.v. of fluid being administered is actually a newly created medication, or a placebo. Entering into that kind of study means placing faith in the importance of the study, not necessarily in any improvement that might be seen by the patient themselves.

There are many benefits to participating in a clinical trial. They offer a level of care that may be a step up from the standard if the treatment you are receiving is found to be effective. Participation can empower a patient and allow them take a lead role in their treatment plan. The psychological effect of this can be beneficial to many patients - feeling "helpless" is a common complaint of cancer patients who are undergoing cancer treatment and request counseling support. Finally, participation in clinical trials allows patients to become part of the important work being done to improve cancer treatment and find cures on a national and global scale. The ongoing legacy of cancer trial participants is significant.

Of course, there can be drawbacks to participation, and patients have to discuss them with their physician as well. There could be side-effects that doctors are not yet aware of. Even if the new treatment has benefits, it may not work on every patient. Health insurance does not always cover all the costs of a research study. New treatments may simply not be any better than the standard of care, which would mean that money spent and side-effects endured may be of no benefit to the individual patient. That's where the ongoing legacy comes in... the more people that are involved in trials, the more quickly the most effective treatment options and cures will be discovered.

More information on clinical trials being conducted in Northwest Arkansas is available on the Highlands Oncology Group website. Their research staff is on the fore-front of the cancer fight and can provide additional information for patients interested in looking at all their treatment options.

Cancer Prevention: Eat to Defeat!

Most of us have the general understanding that some foods are "good" for us and others are "bad". Food, and our relationship with it, has become part of the daily dialogue at work, school, and even on the nightly news. Recent reports say that 1 in 3 adults are considered obese and our kids are following our example and becoming obese themselves.

But even after reading the statistics, it's still difficult for most of us to include enough fruits, vegetables and whole grains in our diets to meet the recommended daily intake and to reduce fats, sugars and empty calories in our meals. You already know that dietary changes can change your body shape and make you "healthier", but would it make a difference in your eating habits to know that some foods may actually help prevent cancer?
 

We mentioned in this month's first blog post that many cancers include "obesity" in their list of risk factors. From the Centers for Disease Control: 

"Research has shown that being overweight or obese substantially raises a person's risk of getting endometrial (uterine), breast, prostate, and colorectal cancers. Overweight is defined as a body mass index (BMI) of 25 to 29, and obesity is defined as a BMI of 30 or higher."

In addition to reducing the risk of obesity, some foods have been found to be beneficial because of health benefits they provide in and of themselves. Antioxidants and phytochemicals in particular have been getting a lot of attention as possible G.I. Joe soldiers in the battle against many diseases, cancer included. There are, in fact, seven "Super Foods" that are recommended for inclusion in any diet being consumed with cancer-prevention in mind. Here's the list, condensed from WebMD:

GARLIC

The same sulfur compounds causing garlic's distinctive odor may also stop cancer-causing substances from forming in your body, speed DNA repair, and kill cancer cells. It also battles bacteria, including H. pylori (connected to some ulcers and stomach cancer), and it reduces the risk of colon cancer. To get the most benefit, peel and chop the cloves and let them sit 15 to 20 minutes before cooking to activate enzymes and release the sulfur-containing compounds that have the most protective effect. Experts say that using garlic supplements does not show the same benefits that the whole cloves do.

BROCCOLI

Many cruciferous vegetables such as cabbage, kale, and cauliflower contain phytochemicals called glucosinolates, which produce protective enzymes that are released when you chew the raw veggie, rupturing the cell walls. Your body also produces those enzymes in the intestines, and they are activated when the raw (or gently cooked) veggies are digested. 

Broccoli and its cousins are most protective against cancers of the mouth, esophagus, and stomach, but research is also being conducted on sulforaphane, another chemical found in cruciferous vegetables that might reduce cancer risk by detoxifying harmful substances (such as smoke and other environmental pollutants) in the body and act as an antimicrobial agent by attacking the bacterium H. pylori.

TOMATOES

The red coloring that makes it easy to spot a ripe specimen also makes them a potential weapon against prostate cancer. That red hue comes from a phytochemical called lycopene, a powerful antioxidant, which is most concentrated in tomatoes. Several ongoing studies suggest that a lycopene-rich diet is connected to a reduced risk of prostate cancer. In laboratory tests, lycopene has stopped other types of cancer cells from growing, including breast, lung, and endometrial (the lining of the uterus). Researchers speculate that lycopene protects cells from damage that could lead to cancer by boosting the immune system and interfering with abnormal cell growth. 

To get the most benefit, eat cooked or processed tomatoes, including tomato juice and pizza sauce. Processing makes the cancer-fighting compounds more available to your body because heat breaks down the plant's cell walls. If you just aren't a fan of tomatoes, you can get a reduced amount of its benefits from lycopene in watermelon, pink grapefruit, or red bell peppers.

STRAWBERRIES

Berries of all kinds have been getting a lot of attention lately. Research points to possible protection against heart disease and memory decline as well as cancer. In a recent study, berry extracts slowed the growth of cancer cells; specifically, strawberry and black raspberry extracts had the greatest impact on colon cancer cells. Strawberries are rich in antioxidants such as vitamin C and ellagic acid. 

 

In laboratory tests, ellagic acid seems to have anticancer properties that rev up enzymes, which destroy cancer-causing substances and slow the growth of tumors. They also contain flavonoids, which suppress an enzyme that damages DNA and has been linked to lung cancer. Other types of berries, all rich in flavonoids, that are worth adding to your grocery basket include raspberries, blackberries, blueberries, and cranberries. Blueberries are packed with anthocyanins, which reduce inflammation and are one of the most powerful antioxidants. Some consider berries and cruciferous vegetables the most powerful protective foods available to consumers.

CARROTS

One of the easiest vegetables eat, carrots are packed with disease-fighting nutrients. They contain beta-carotene, an antioxidant scientists believe may protect cell membranes from toxin damage and slow the growth of cancer cells. Carrots also deliver other vitamins and phytochemicals that might guard against cancers of the mouth, esophagus, and stomach. Some studies suggest carrots protect against cervical cancer, perhaps because they supply antioxidants that could battle HPV (human papilloma virus), the major cause of cervical cancer. Plus, carrots contain falcarinol, a natural pesticide, which has been found to reduce the risk of developing cancerous tumors in lab tests. 

 

Unlike some foods that lose their potency when cooked, carrots (and tomatoes, spinach, mushrooms, asparagus, cabbage, and peppers) experience an increase in their antioxidant levels when exposed to heat.

SPINACH

Maybe you've heard that lutein, an antioxidant, is good for your eyes. Early results of research shows it might also play a role in guarding against cancer. Spinach is rich in lutein and zeaxanthin, carotenoids that remove unstable molecules called free radicals from your body before they damage it. They're found in spinach and other dark green leafy vegetables, and some studies show they could protect against cancer of the mouth, esophagus, and stomach. 

An NIH/AARP study of more than 490,000 people found that those who ate more spinach were less likely to develop esophageal cancer. Some studies suggest the carotenoids in spinach and other foods reduce the risk of ovarian, endometrial, lung, and colorectal cancer, too. Throw in folate and fiber, which researchers think might trim the risk of certain cancers, and you've got nutritional powerhouse in every dark green leaf. Folate helps your body produce new cells and repair DNA, and is especially important for women of childbearing age because it can prevent neural tube defects in a developing fetus. 

You'll get the most lutein from raw or lightly cooked spinach. Enjoy it in a salad, steamed, or sautéed with garlic and olive oil, or stirred into soups. For a change (but reduced benefit), substitute kale, collard greens, Swiss chard, or romaine lettuce.

WHOLE GRAINS

You may have noticed that a lot of foods - even sugary kids' cereals and frozen pizzas - are adding whole-grain components to their ingredients. It's a result of revised federal nutrition guidelines that recommend half of all the grains you eat -- rice, cereal, and even chips -- should be whole grains, not processed. Whole grains deliver plenty of fiber, which has been suspected to reduce the risk of colon cancer. 

Experts are not yet sure how the fiber/cancer connection works, but whole grains also contain other substances that might battle cancer, including lignans, which act as antioxidants, and saponins, which could keep cancer cells from multiplying. Look for bread labeled "100% whole wheat" rather than simply "wheat bread," which likely contains refined grains. For even more lignans, choose a whole wheat bread sprinkled with flax or sesame seeds.

So, now you know WHAT to eat, but do you know how much of these foods makes up a serving? Here's an article that can help. Habits can be tough to break, and family-members' preferences can also present a challenge when trying to add some Super Foods to your diet. Use these tips to make changes to your family's meals in small steps. Remember, small steps may be necessary at first, but they still start you off in the right direction.

Cancer Prevention: Know Your Moles

Has a mole that you’ve had since you were a child gone through some changes? Maybe it's a different shape or color, or it's just getting thicker and a little itchy? Have you recently found a new mole that doesn't look like the rest? If you can answer yes to at least one of these questions, then want to consider getting screened by a dermatologist for skin cancer. 

The internet is an abundant source of information about cancer types, prevention, and treatments, but all that information can be overwhelming and confusing. In keeping with our cancer prevention theme through the month of February, we have gathered some great information from our Certified Health Education Specialist, Casey Shelor. We hope this post will help eliminate some confusion with respect to the prevention of skin cancer.

Skin cancer is the most common form of cancer in the United States. The two most common types of skin cancer—basal cell and squamous cell carcinomas—are highly curable. However, melanoma, the third most common skin cancer, is more dangerous. 

Here are some tips on reducing the chance of being diagnosed with any type of skin cancer, from the Centers for Disease Control & Prevention.

Protection from ultraviolet (UV) radiation is important all year round, not just during the summer or at the beach. UV rays from the sun can reach you on cloudy and hazy days, as well as bright and sunny days. UV rays also reflect off of surfaces like water, cement, sand, and snow. Indoor tanning (using a tanning bed, booth, or sunlamp to get tan) exposes users to UV radiation.

The hours between 10 a.m. and 4 p.m. daylight savings time (9 a.m. to 3 p.m. standard time) are the most hazardous for UV exposure outdoors in the continental United States. UV rays from sunlight are the greatest during the late spring and early summer in North America. The CDC recommends several easy options for protection from UV radiation:

• Seek shade, especially during midday hours. You can reduce your risk of skin damage and skin cancer by seeking shade under an umbrella, tree, or other shelter before you physically feel a need for relief from the sun. Your best bet to protect your skin is to use sunscreen or wear protective clothing when you're outside—even when you're in the shade.

• Wear clothing to protect exposed skin. Loose-fitting, long-sleeved shirts and long pants made from tightly woven fabric offer the best protection from the sun's UV rays. Keep in mind that a typical T-shirt has an SPF rating lower than 15, so use other types of protection as well. Also, a wet T-shirt offers much less UV protection than a dry one. Darker colors may offer more protection than lighter colors. If wearing this type of clothing isn't practical, at least try to wear a T-shirt or a beach cover-up.

• Wear a hat. For the best protection, wear a hat with a brim all the way around that shades your face, ears, and the back of your neck. A tightly woven fabric, such as canvas, works best to protect your skin from UV rays. Avoid straw hats with holes that let sunlight through. A darker-colored hat may offer more UV protection. If you are wearing a ball cap, don't forget to protect the back of your neck and tops of your ears with clothing and/or sunscreen.

• Wear sunglasses. They protect your eyes from UV rays and reduce the risk of cataracts while also protecting the tender skin around your eyes from sun exposure. Wrap-around sunglasses work best because they block UV rays from sneaking in from the side, and sunglasses that block both UVA and UVB rays offer the best protection. Most sunglasses sold in the United States, regardless of cost, meet this standard, but check the labels.

• Use sunscreen. Choose sunscreen with sun protective factor (SPF) 15 or higher, and both UVA and UVB protection. The sun's UV rays can damage your skin in as little as 15 minutes. Put on sunscreen before you go outside, even on slightly cloudy or cool days. Apply a thick layer (rub it in until it's gone) on all parts of exposed skin and get help for hard-to-reach places like your back. Sunscreen does wear off, so all sunscreens (even the "waterproof" ones) need to be reapplied after swimming, sweating or being outside for more than two hours. Check the sunscreen's expiration date. Sunscreen without an expiration date has a shelf life of no more than three years, but its shelf life is shorter if it has been exposed to high temperatures.

• Avoid indoor tanning. Using a tanning bed, booth, or sunlamp to get tan has been linked to an increased risk of skin cancers - including melanoma - and cancers of the eye. A recent study found that using a tanning bed - any type and for any length of time - increases a person's risk of melanoma by 74%. Some are likening the use of tanning beds by teens to the use of cigarettes, saying that it is a carcinogen and should be regulated in people under the age of 18. You have to ask yourself: Is a golden tan really worth dying for?

As always - know the facts, and do your part to protect yourself and your loved-ones from the potentially deadly effects of cancer. Skin cancer is preventable, and making the right choices can save your life.

Cancer Prevention: Tobacco Use

As we shared last week, the number one thing you can do to reduce your risk of cancer is to stop using tobacco. More specifically, to stop smoking cigarettes. By now, everyone knows that smoking is linked to lung cancer, but did you know that lung cancer is the leading cause of cancer deaths in the United States for men and women. 90% of lung cancer deaths in men and 80% of lung cancer deaths in women are directly linked to smoking. Lung cancer is also one of the costliest cancers - contributing to approximately $263.8 billion in costs to patients and insurance companies in the U.S. in 2010.

And if that news was not sobering enough, smoking is also linked to many other types of cancer, including cancers of the throat, mouth, nasal cavity, esophagus, stomach, pancreas, kidney, bladder, and cervix, and acute myeloid leukemia.

Now that we've got your attention, we're going to share some information about how you can stop smoking.

We know that smoking is one of the hardest habits to break, simply because there is an addiction involved. Nicotine is the drug in tobacco that causes addiction. It is absorbed and enters the bloodstream through the lungs when smoke is inhaled, and through the lining of the mouth when tobacco is chewed or used as oral snuff or for non-inhaled pipe and cigar smoking.

Nicotine is a psychoactive drug with stimulant effects on the electrical activity of the brain. It also has calming effects, especially at times of stress, as well as effects on hormonal and other systems throughout the body. Although its subjective effects are less dramatic and obvious than those of some other addictive drugs, smoking doses of nicotine causes activation of "pleasure centers" in the brain, which may explain the pleasure, and addictiveness of smoking.

Studies show that tobacco use usually begins in early adolescence, and those who begin smoking at an early age are more likely to develop severe nicotine addiction than those who start later. Each day, more than 4,800 adolescents smoke their first cigarette, and 42 percent of them go on to become regular smokers. (from ehealthmd.com)

So, what can you do to stop? Quitting cold turkey is generally not effective, for reasons detailed above. But there is help available. Google "how to quit smoking" and you'll find countless articles, programs and could easily get bogged down in the many different suggestions and plans offered. There are telephone helplines, various nicotine replacement options available by prescription, and prescription medications as well. Some people swear by alternative therapies such as hypnosis, acupuncture, herbal remedies and even electronic cigarettes. The wide range of options is detailed here at the American Cancer Society website.

For our neighbors in Northwest Arkansas, we have an even better suggestion. At Hope Cancer Resources we are fortunate to have a Certified Tobacco Treatment Specialist on staff who can help you create a personal plan that is best suited to you, your lifestyle, and the resources available. Whether you have decided for yourself that it's time to quit - or if you know someone who needs information, contact Casey Shelor by email or at 479-361-5847 and let her help you develop a plan. It may be the most important decision you can make for your health, and for the people you love.